Proenkephalin-B/PDYN is a proprotein that is cleaved proteolytically to yield the peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. The kappa-opioid receptors are triggered by these peptides, which bind to them. Dynorphin is involved in the modulation of mood after administration of a variety of psychoactive drugs, including cocaine. Spinocerebellar ataxia 23, which causes loss of motor control, is one of the most prevalent neurodegenerative diseases associated with PDYN. PDYN is also linked to cocaine addiction and other neurodegenerative diseases. GPCR and peptide ligand-binding receptors are two PDYN linked processes. Human Proenkephalin-B/PDYN Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Proenkephalin-B/PDYN Recombinant Protein (RPES0381)
Product Code:
RPES0381
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
ADCA, PENKB, SCA23, PDYN, Dynorphin B, Big Dyn
Accession:
P01213
Sequence:
Asp21-Ala254
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Proenkephalin-B is produced by our Mammalian expression system and the target gene encoding Asp21-Ala254 is expressed with a 6His tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
27.3 kDa
AP Mol Mass:
35 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS,pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
