Recombinant Human QPRT/QPRTase Protein (His Tag) (RPES3590)

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ELISA Kit Technical Manual

Recombinant Human QPRT/QPRTase Protein (His Tag)

Background:Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
Name:Recombinant Human QPRT/QPRTase Protein (His Tag)
Assay Genie SKU:RPES3590
Synonyms:Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]; Quinolinate Phosphoribosyltransferase [Decarboxylating]; QAPRTase; QPRTase; QPRT
Expression host:E.coli
Sequence:Met 1-His297
Mol Mass:33.0 kDa
AP Mol Mass:34 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
UniProt Protein Details:

Protein type:Transferase; EC; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function:nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity

Biological Process: NAD biosynthetic process; NAD metabolic process; protein oligomerization

NCBI Summary:This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Code:Q15274
NCBI GenInfo Identifier:296439291
NCBI Gene ID:23475
NCBI Accession:Q15274.3
UniProt Secondary Accession:Q15274,Q53XW7, Q96G22, Q9BSG6,
UniProt Related Accession:Q15274
Molecular Weight:30,846 Da
NCBI Full Name:Nicotinate-nucleotide pyrophosphorylase
NCBI Synonym Full Names:quinolinate phosphoribosyltransferase
NCBI Official Symbol:QPRT  
NCBI Official Synonym Symbols:QPRTase; HEL-S-90n  
NCBI Protein Information:nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Protein Name:Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names:Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
Protein Family:Nicotinate-nucleotide pyrophosphorylase
UniProt Gene Name:QPRT  
UniProt Entry Name:NADC_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
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