Human QPRT Recombinant Protein (RPPB2238)
- SKU:
- RPPB2238
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15274
- Research Area:
- Enzymes
Description
| Product Name: | Human QPRT Recombinant Protein |
| Product Code: | RPPB2238 |
| Size: | 20µg |
| Species: | Human |
| Target: | QPRT |
| Synonyms: | Quinolinate phosphoribosyltransferase , QPRTase, QAPRTase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The QPRT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH |
QPRT is a key enzyme in the catabolism of quinolinate. QPRT is in between the tryptophannicotinamide adenine dinucleotide (NAD) pathway, resulting in the production of nicotinic acid, carbon dioxide and pyrophosphate. Rise of QPRT levels in the brain is related to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
QPRT Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 317 amino acids (1-297 a.a.) and having a molecular mass of 32.9 kDa. The QPRT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.4.2.19; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasm; cytosol Molecular Function:nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity Biological Process: NAD biosynthetic process; NAD metabolic process; protein oligomerization |
| NCBI Summary: | This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q15274 |
| NCBI GenInfo Identifier: | 296439291 |
| NCBI Gene ID: | 23475 |
| NCBI Accession: | Q15274.3 |
| UniProt Secondary Accession: | Q15274,Q53XW7, Q96G22, Q9BSG6, |
| UniProt Related Accession: | Q15274 |
| Molecular Weight: | 30,846 Da |
| NCBI Full Name: | Nicotinate-nucleotide pyrophosphorylase |
| NCBI Synonym Full Names: | quinolinate phosphoribosyltransferase |
| NCBI Official Symbol: | QPRT�� |
| NCBI Official Synonym Symbols: | QPRTase; HEL-S-90n�� |
| NCBI Protein Information: | nicotinate-nucleotide pyrophosphorylase [carboxylating] |
| UniProt Protein Name: | Nicotinate-nucleotide pyrophosphorylase [carboxylating] |
| UniProt Synonym Protein Names: | Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase |
| Protein Family: | Nicotinate-nucleotide pyrophosphorylase |
| UniProt Gene Name: | QPRT�� |
| UniProt Entry Name: | NADC_HUMAN |
