Receptor Tyrosine Kinaselike Orphan Receptor 2(ROR2) belongs to the protein kinase superfamily, Tyr protein kinase family and ROR subfamily. It is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. ROR2 promotes osteogenesis, binds YWHAB and Interacts with WTIP. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cellpolarization, and migration. ROR2 has also been shown to have very little tyrosine kinase activity in vitro and may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Recombinant Human ROR2 is produced by our Mammalian expression system and the target gene encoding Glu34-Gly403 is expressed with a 6His tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
42.2 kDa
AP Mol Mass:
50-60 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
