S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells; and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release; inhibition of microtubule assembly; and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1; and recently; S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly; reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.
Product Name:
Human S100A1 Recombinant Protein (RPES0837)
Product Code:
RPES0837
Size:
100 µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
S100,S100-alpha,S100A
Accession:
NP_006262.1
Sequence:
Gly 2-Ser94
Fusion tag:
N-Fc
Activity:
Measured by its ability to bind biotinylated Human Fc-S100B in functional Elisa.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human S100A1 (NP_006262.1) (Gly 2-Ser94) was expressed with the N-terminal fused Fc region of human IgG1.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
