HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type of integral membrane glycoprotein. The KIM-1 protein is highly expressed in the kidney and testis. It has been linked to asthma, allergy, and autoimmune disease. KIM-1 protein contains a ligand known as IgA1lambda, and their interaction has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It was verified that KIM-1 is a human urinary renal disease biomarker. Furthermore, KIM-1 protein is a novel signaling molecule linked to flow-induced calcium signaling. Human TIM1/HAVCR1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) with a C-terminal polyhistidine tag was expressed and purified.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
30 kDa
AP Mol Mass:
90-110 kDa
Formulation:
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
