Description
| Product Name: | Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA, C-Fc) |
| Product Code: | RPES6356 |
| Size: | 10µg |
| Species: | Human |
| Expression Host: | HEK293 Cells |
| Synonyms: | Tumor-associated calcium signal transducer 2, Membrane component chromosome 1 surface marker 1, Cell surface glycoprotein Trop-2, TACSTD2, TROP2 |
| Mol Mass: | 54.8 kDa |
| AP Mol Mass: | 60-80 kDa |
| Tag: | C-Fc |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Bio Activity: | Immobilized Human TROP-2-Fc at 2μg/ml (100 μl/well) can bind Anti-Human TROP-2 mAb : Biotinylated by NHS-biotin prior to testing. The ED50 of Anti-Human TROP-2 mAb is 20.54 ng/ml. |
| Sequence: | His27-Thr274 |
| Accession: | P09758 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions. |
