CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.
Product Name:
Mouse CD302/CLEC13A Recombinant Protein (RPES0113)
Product Code:
RPES0113
Size:
100 µg
Species:
Mouse
Expressed Host:
HEK293 Cells
Synonyms:
1110055L24Rik,AI159627
Accession:
Q9DCG2-2
Sequence:
Met 1-His 156
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of mouse CD302 isoform 2 (Q9DCG2-2) (Met 1-His 156) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 93 % as determined by SDS-PAGE
Mol Mass:
42.6 kDa
AP Mol Mass:
48 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
