CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation.
Product Name:
Mouse CD48 Recombinant Protein (RPES0146)
Product Code:
RPES0146
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
CD48, BLAST1, BCM1, SLAMF2,SLAM Family Member 2,AI449234, AW610730, Bcm-1, BLAST-1, MEM-102,Sgp-60
Accession:
NP_031675.1
Sequence:
Phe23-Arg216
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse SLAM Family Member 2 is produced by our Mammalian expression system and the target gene encoding Phe23-Arg216 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
23.1 kDa
AP Mol Mass:
45-50 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
