Limitin, also called IFN-?, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN-?, IFN-β, and IFN-? and binds to the IFN-?/β receptors. Like IFN-? and IFN-β, limitin has antiproliferative, immunomodulatory, and antiviral properties, it is unique in lacking influence on myeloid and erythroid progenitors. Similar dose requirement between limitin and IFN-? was observed for the enhancement of cytotoxic T lymphocyte activity, the augmentation of MHC class I expression, and the growth inhibition of a myelomonocytic leukemia cell line.
Product Name:
Mouse IFN-zeta/Limitin Recombinant Protein (RPES1489)
Recombinant Mouse Limitin is produced by our Mammalian expression system and the target gene encoding Leu22-Arg182 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
19.5 kDa
AP Mol Mass:
19 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
