Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.
Product Name:
Mouse IGFBP6/IGFBP-6 Recombinant Protein (RPES1117)
Product Code:
RPES1117
Size:
10µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp6, IBP6, IGF binding protein 6, insulin-like growth factor-binding protein 6
Accession:
P47880
Sequence:
Ala26-Gly238
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Mouse Insulin-Like Growth Factor-Binding Protein 6 is produced by our Mammalian expression system and the target gene encoding Ala26-Gly238 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
23.7 kDa
AP Mol Mass:
28 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, EDTA,DTT,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
