Description
Recombinant Mouse IL-23R Protein
The Recombinant Mouse IL-23R Protein is a high-quality recombinant protein designed for murine biological research applications. This protein serves as an essential reagent in mouse model studies, comparative immunology research, and preclinical therapeutic evaluations, enabling scientists to investigate IL-23R biology and its relevance to human disease mechanisms through translational research approaches.
This product (SKU: RPCB0713) is produced using HEK293 cells and features a C-Fc tag for convenient detection and purification. The protein exhibits a calculated molecular weight of 67.4 kDa with an observed molecular weight of 90-110 kDa under denaturing conditions, achieving ≥ 95 % as determined by SDS-PAGE., ensuring exceptional quality and consistency for research applications.
Key Features
| High Purity by Affinity Chromatography | |
| Mammalian & Bacterial Expression Systems | |
| High lot-to-lot consistency via strict QC |
| Product Name: | Recombinant Mouse IL-23R Protein |
| SKU: | RPCB0713 |
| Size: | 10 μg , 50 μg |
| Reactivity: | Mouse |
| Synonyms: | Interleukin-23 receptor, Il23r, IL-23 receptor, IL-23R, interleukin 23 receptor |
| Tag: | C-Fc |
| Expression Host: | HEK293 cells |
| Calculated MW: | 67.4 kDa |
| Observed MW: | 90-110 kDa |
| Gene ID: | 209590 |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Mouse IL-23R Protein (RPCB0713), tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 1 EU/μg of the protein by LAL method. |
| Purity: | ≥ 95 % as determined by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.2 μM filtered solution of PBS, pH 7.4Contact us for customized product form or formulation. |
| Reconstitution: | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β 1 (IL12R β 1) and IL12R β 2, is a type Icytokine receptor for IL23. IL23R is comprised of two subunits, the IL12R β 1 subunit, which is shared withseveral cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cellsand mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphismsof the IL23R gene were reported to be associated with susceptibility to inflammatory diseases andautoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory boweldiseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
 | Recombinant Mouse IL-23R Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue. |
