Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
The Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is a high-quality recombinant protein designed for murine biological research applications. This protein serves as an essential reagent in mouse model studies, comparative immunology research, and preclinical therapeutic evaluations, enabling scientists to investigate Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer biology and its relevance to human disease mechanisms through translational research approaches.
This product (SKU: RPCB2173) is produced using HEK293 cells and features a C-His tag for convenient detection and purification. The protein exhibits a calculated molecular weight of 111.6 kDa (ITGAV) & 79.2 kDa (ITGB6) with an observed molecular weight of 90-140 kDa under denaturing conditions, achieving ≥ 95 % as determined by Tris-Bis PAGE;≥ 95 % as determined by HPLC., ensuring exceptional quality and consistency for research applications.
Key Features
High Purity by Affinity Chromatography
Mammalian & Bacterial Expression Systems
High lot-to-lot consistency via strict QC
Product Name:
Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
High quality, high purity and low endotoxin recombinant Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (RPCB2173), tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed.
Endotoxin:
< 1 EU/μg of the protein by LAL method.
Purity:
≥ 95 % as determined by Tris-Bis PAGE;≥ 95 % as determined by HPLC.
Reconstitution:
Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
Storage:
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Mouse ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
Immobilized Mouse ITGAV&ITGB6, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Mouse GARP&Latent TGF beta 1 Complex, His Tag with the EC50 of 89.3ng/ml determined by ELISA.
