Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-? and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -??, -ββ and -?β. PDGFR? and PDGFRβ are members of the class III RTK family. Inappropriate PDGFR? and PDGFRβ signaling has been linked to a number of proliferative disorders.
Product Name:
Mouse PDGFRa/CD140a Recombinant Protein (RPES2526)
Recombinant Mouse Platelet-derived growth factor receptor alpha is produced by our Mammalian expression system and the target gene encoding Leu25-Glu524 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
56.9 kDa
AP Mol Mass:
80-120kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
