Rat EGFR/ErbB1 Recombinant Protein (RPES5227)

SKU:
RPES5227
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Rat
€499

Description

ELISA Kit Technical Manual

Recombinant Rat EGFR/ErbB1 Protein (His Tag)(Active)

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Background:As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-?, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Name:Recombinant Rat EGFR/ErbB1 Protein (His Tag)(Active)
Size:50µg
Assay Genie SKU:RPES5227
Synonyms:EGFR
Species:Rat
Expression host:HEK293 Cells
Sequence:Met1-Ser646
Accession:E7CXR8
Mol Mass:70.7 kDa
AP Mol Mass:9310 kDa
Tag:C-His
Bio Activity:1. Measured by its ability to bind recombinant human EGF-Fc in a functional ELISA.2. Measured by its ability to bind recombinant mouse EGF-Fc in a functional ELISA.
Purity:> 98 % as determined by SDS-PAGE
Endotoxin:
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4
Reconstitution:Please refer to the printed manual for detailed information.
Application:Functional ELISA