GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.Immune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
Product Name:
Rat GITR/TNFRSF18 Recombinant Protein (RPES0581)
Product Code:
RPES0581
Size:
100 µg
Species:
Rat
Expressed Host:
HEK293 Cells
Synonyms:
TNFRSF18
Accession:
Q5M835
Sequence:
Met1-Lys121
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method
Protein Construction:
A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
37.7 kDa
AP Mol Mass:
47 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
