RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. In addition, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and peripherin could play an important role in CMT2B neuropathy.
Product Name:
Rat RAB7A/Rab-7a Recombinant Protein (RPES3277)
Product Code:
RPES3277
Size:
100 µg
Species:
Rat
Expressed Host:
E. coli
Synonyms:
Rab7
Accession:
NP_076440.1
Sequence:
Met1-Cys207
Fusion tag:
N-His
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the rat Rab7a (NP_076440.1) (Met1-Cys207) was expressed with a polyhistidine tag at the N-terminus.
Purity:
> 90 % as determined by SDS-PAGE
Mol Mass:
25.7 kDa
Formulation:
Lyophilized from sterile PBS, 10 % glycerol
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
