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Rat SCF/c-Kit Ligand Recombinant Protein (RPES4293)

SKU:
RPES4293
Product Type:
Recombinant Protein
Species:
Rat
Research Area:
Cell Biology
$360
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Description

system_update_altDatasheet

Rat SCF/c-Kit Ligand Recombinant Protein

SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.