Description
| Product Name: | Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc) |
| Product Code: | RPES6792 |
| Size: | 10µg |
| Species: | Rhesus Macaque |
| Expression Host: | HEK293 Cells |
| Synonyms: | Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2 |
| Mol Mass: | 110.6 kDa |
| AP Mol Mass: | 120-140 kDa |
| Tag: | C-Fc |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Bio Activity: | Immobilized 2019-nCoV S Protein RBD-SD1-mFcat 2μg/ml (100 μl/well) can bind Rhesus Macaque ACE-2-Fc. The ED50 of Recombinant Rhesus Macaque ACE-2-Hisis 96 ng/ml. |
| Sequence: | Gln18-Val739 |
| Accession: | ACI04564.1 |
| Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation: | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Not Applicable |
| Background: | Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function. |
