The REEP3 Polyclonal Antibody (PACO36962) is an essential tool for researchers studying REEP3, a key protein involved in regulating endoplasmic reticulum morphology and function. This antibody, derived from rabbit polyclonal sources, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the REEP3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and neuroscience research.REEP3, also known as receptor expression-enhancing protein 3, is crucial for maintaining proper ER structure and function, playing a role in processes such as lipid metabolism and organelle dynamics.
Dysregulation of REEP3 has been implicated in various neurodegenerative diseases and metabolic disorders, highlighting its importance in cellular homeostasis. By investigating the function of REEP3, researchers can gain valuable insights into the mechanisms underlying these conditions, potentially leading to the development of novel therapeutic strategies.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO36962 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO36962 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human heart tissue using PACO36962 at dilution of 1:100.
Background:
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Synonyms:
Receptor expression-enhancing protein 3, REEP3, C10orf74
UniProt Protein Function:
REEP3: a multi-pass membrane protein that interacts with odorant receptors and enhances their cell surface expression. Two alternatively spliced human isoforms have been described.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 10q21.3Cellular Component: microtubule; endoplasmic reticulum membrane; integral to membraneBiological Process: mitosis; mitotic nuclear envelope reassembly; cell division; nuclear membrane organization and biogenesis
