The RER1 Antibody (PAC029460) is a highly specific polyclonal antibody designed for research involving the RER1 protein, a key player in protein trafficking and quality control in the endoplasmic reticulum (ER). This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.The RER1 protein is essential for maintaining ER homeostasis and ensuring proper folding and trafficking of proteins within the cell. Its role in protein quality control makes it a crucial target for studies in cell biology and molecular biology, particularly in understanding ER function and protein processing.
By utilizing the RER1 Antibody, researchers can effectively detect and analyze the RER1 protein in various cell types, providing valuable insights into protein trafficking mechanisms and potential therapeutic targets for diseases related to ER dysfunction. This antibody is a valuable tool for researchers looking to advance our understanding of protein quality control in the ER and its impact on cellular homeostasis.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO29460 at dilution of 1:100.
Immunofluorescent analysis of 293T cells using PACO29460 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO29460 at dilution of 1:100.
Background:
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
Synonyms:
Protein RER1, RER1
UniProt Protein Function:
RER1: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Belongs to the RER1 family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p36Cellular Component: cell surface; ER-Golgi intermediate compartment; Golgi apparatus; integral to Golgi membrane; plasma membraneMolecular Function: acetylcholine receptor bindingBiological Process: retrograde vesicle-mediated transport, Golgi to ER
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]
