Description
RGS1 Antibody (PACO01426)
The RGS1 Monoclonal Antibody (PACO01426) is a valuable tool for researchers studying RGS1, a key regulator of G protein signaling. This antibody, generated in-house using state-of-the-art techniques, specifically targets the RGS1 protein and is highly reactive with human samples. It has been validated for use in various applications, including Western blot and immunofluorescence, allowing for accurate detection and analysis of RGS1 in different cell types.RGS1 is known for its role in modulating immune responses and has been implicated in various diseases, including autoimmune conditions and cancer.
By targeting RGS1, researchers can gain important insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets. This antibody is a valuable asset for studies focusing on immune regulation and signal transduction, making it a must-have for immunology and cancer research laboratories.
| Antibody Name: | RGS1 Antibody |
| Antibody SKU: | PACO01426 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human RGS1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RGS1; 1R20; BL34; IER1; Regulator of G-protein signaling 1; RGS1; B-cell activation protein BL34; Early response protein 1R20 |
| UniProt Protein Function: | RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08116 |
| NCBI GenInfo Identifier: | 229470360 |
| NCBI Gene ID: | 5996 |
| NCBI Accession: | Q08116.3 |
| UniProt Secondary Accession: | Q08116,Q07918, Q9H1W2, B2RDM9, B4DZY0, |
| UniProt Related Accession: | Q08116 |
| Molecular Weight: | 19,134 Da |
| NCBI Full Name: | Regulator of G-protein signaling 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 1 |
| NCBI Official Symbol: | RGS1Â Â |
| NCBI Official Synonym Symbols: | 1R20; BL34; IER1; IR20; HEL-S-87Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 1 |
| UniProt Protein Name: | Regulator of G-protein signaling 1 |
| UniProt Synonym Protein Names: | B-cell activation protein BL34 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS1Â Â |
| UniProt Entry Name: | RGS1_HUMAN |
