Description
RGS11 Antibody (PACO16975)
The RGS11 Polyclonal Antibody (PAC016975) is a vital tool for studying the protein RGS11, a regulator of G protein signaling 11. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards RGS11 in human samples, making it an excellent choice for Western blot applications.RGS11 is involved in modulating intracellular signaling pathways by regulating G protein-coupled receptor signaling. Its role in signal transduction and cellular responses makes it a key player in various physiological processes. The use of the RGS11 Polyclonal Antibody allows for the detection and quantification of RGS11 protein levels in a variety of cell types, providing valuable insights into its function and potential implications in diseases such as neurological disorders and cardiovascular conditions.
Researchers interested in investigating the intricate mechanisms of signal transduction and G protein signaling pathways can benefit greatly from the reliability and specificity of the RGS11 Polyclonal Antibody. Its application extends to studies in neuroscience, cardiology, and pharmacology, offering a valuable tool for expanding our understanding of cellular communication and molecular pathways.
| Antibody Name: | RGS11 Antibody (PACO16975) |
| Antibody SKU: | PACO16975 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RGS11 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16975(RGS11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the α subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein α subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. |
| Synonyms: | regulator of G-protein signaling 11 |
| UniProt Protein Function: | RGS11: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; plasma membrane; protein complex Molecular Function:G-protein beta-subunit binding; GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013] |
| UniProt Code: | O94810 |
| NCBI GenInfo Identifier: | 6174947 |
| NCBI Gene ID: | 8786 |
| NCBI Accession: | O94810.2 |
| UniProt Secondary Accession: | O94810,O75883, Q4TT71, Q4TT72, |
| UniProt Related Accession: | O94810 |
| Molecular Weight: | 50,727 Da |
| NCBI Full Name: | Regulator of G-protein signaling 11 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 11 |
| NCBI Official Symbol: | RGS11Â Â |
| NCBI Official Synonym Symbols: | RS11Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 11 |
| UniProt Protein Name: | Regulator of G-protein signaling 11 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS11Â Â |
| UniProt Entry Name: | RGS11_HUMAN |
