The RGS12 Polyclonal Antibody (PACO03065) is a crucial tool for research involving RGS12, a protein involved in various cellular signaling pathways. This antibody is produced in rabbits and has high reactivity with human samples, making it a reliable tool for Western blot applications. By specifically binding to the RGS12 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell signaling, cancer research, and neuroscience.RGS12, also known as Regulator of G-protein signaling 12, plays a pivotal role in modulating G-protein coupled receptor signaling, which is essential for numerous physiological processes.
Its involvement in cellular responses to external stimuli and intracellular signaling cascades makes it a key target for understanding cellular communication and disease mechanisms. Research on RGS12 is crucial for developing targeted therapies for diseases like cancer, neurological disorders, and cardiovascular conditions that are influenced by G-protein signaling pathways.Overall, the RGS12 Polyclonal Antibody is a valuable tool for researchers studying cell signaling pathways, cancer biology, and neurobiology. Its specificity and sensitivity make it an indispensable asset for investigations into the role of RGS12 in normal physiology and disease states.
Antibody Name:
RGS12 Antibody
Antibody SKU:
PACO03065
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human RGS12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RGS12; Regulator of G-protein signaling 12; RGS12
UniProt Protein Function:
RGS12: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, misc.; GAPsChromosomal Location of Human Ortholog: 4p16.3Cellular Component: nuclear matrix; condensed nuclear chromosome; cytoplasm; nucleolus; plasma membrane; nucleusMolecular Function: receptor signaling protein activity; GTPase regulator activity; GTPase activator activityBiological Process: transcription, DNA-dependent; regulation of catalytic activity; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq]
