The RIC3 Polyclonal Antibody (PACO11840) is a valuable tool for researchers studying the RIC3 protein, a chaperone involved in the assembly of nicotinic acetylcholine receptors. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blotting.RIC3 is a critical player in the regulation of neurotransmission, specifically in the formation and function of nicotinic receptors in the nervous system. Dysregulation of RIC3 has been linked to neurological disorders such as Alzheimer's disease and schizophrenia, making it a promising target for therapeutic interventions.
By using the RIC3 Polyclonal Antibody, researchers can explore the role of RIC3 in neurobiology and potentially uncover new insights into the pathogenesis of neurological diseases. Its specificity and reliability make it an essential component of studies aimed at unraveling the molecular mechanisms underlying these conditions.
resistance to inhibitors of cholinesterase 3 homolog (C. elegans);RIC3;AYST720;FLJ11608;PRO1385 ;
UniProt Protein Function:
RIC3: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. Belongs to the ric-3 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11p15.4Cellular Component: cell soma; intracellular membrane-bound organelle; neuron projectionMolecular Function: acetylcholine receptor bindingBiological Process: synaptic transmission, cholinergic
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
