Description
RNASET2 Antibody (PACO16984)
The RNASET2 Polyclonal Antibody (PAC016984) is a valuable tool for researchers studying RNASET2, a promising candidate tumor suppressor gene. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.RNASET2 is a ribonuclease enzyme with potential anti-tumor properties, making it a key player in cancer research. By targeting RNASET2, researchers can investigate its role in inhibiting tumor growth and metastasis, as well as its potential as a therapeutic target for cancer treatment.
This antibody enables the detection and analysis of RNASET2 in different cell types, providing valuable insights into its function and implications for cancer biology.Overall, the RNASET2 Polyclonal Antibody is a versatile tool for researchers interested in exploring the mechanisms underlying cancer development and progression. Its specificity and reliability make it an essential component in studies aiming to uncover the therapeutic potential of RNASET2 in cancer treatment strategies.
| Antibody Name: | RNASET2 Antibody (PACO16984) |
| Antibody SKU: | PACO16984 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RNASET2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16984(RNASET2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16984(RNASET2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. |
| Synonyms: | ribonuclease T2 |
| UniProt Protein Function: | RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Ribonuclease; EC 3.1.27.-; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 6q27 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; lysosome Molecular Function:ribonuclease activity Biological Process: RNA catabolic process Disease: Leukoencephalopathy, Cystic, Without Megalencephaly |
| NCBI Summary: | This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00584 |
| NCBI GenInfo Identifier: | 20139363 |
| NCBI Gene ID: | 8635 |
| NCBI Accession: | O00584.2 |
| UniProt Secondary Accession: | O00584,Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47, B2RDA7, E1P5C3 |
| UniProt Related Accession: | O00584 |
| Molecular Weight: | 14,000 Da |
| NCBI Full Name: | Ribonuclease T2 |
| NCBI Synonym Full Names: | ribonuclease T2 |
| NCBI Official Symbol: | RNASET2Â Â |
| NCBI Official Synonym Symbols: | RNASE6PL; bA514O12.3Â Â |
| NCBI Protein Information: | ribonuclease T2 |
| UniProt Protein Name: | Ribonuclease T2 |
| UniProt Synonym Protein Names: | Ribonuclease 6 |
| Protein Family: | Ribonuclease |
| UniProt Gene Name: | RNASET2Â Â |
| UniProt Entry Name: | RNT2_HUMAN |
