UniProt Protein Function: | Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. |
NCBI Summary: | The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q5XPI4 |
NCBI GenInfo Identifier: | 37588869 |
NCBI Gene ID: | 63891 |
NCBI Accession: | NP_071347.2 |
UniProt Secondary Accession: | Q5XPI4,Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8 Q9H9T2, A1L4Q3, A6NLS5, |
UniProt Related Accession: | Q5XPI4 |
Molecular Weight: | 144 |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF123 |
NCBI Synonym Full Names: | ring finger protein 123 |
NCBI Official Symbol: | RNF123Â Â |
NCBI Official Synonym Symbols: | KPC1; FP1477Â Â |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF123 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF123 |
UniProt Synonym Protein Names: | Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123; RING-type E3 ubiquitin transferase RNF123Curated |
UniProt Gene Name: | RNF123Â Â |