The RPA1N Antibody (PAC011896) is a polyclonal antibody designed for research involving the RPA1N protein, which plays a key role in DNA replication and repair processes. The antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. It binds to the RPA1N protein, allowing for detection and analysis in different cell types, making it suitable for studies in molecular biology and cancer research.
RPA1N, also known as replication protein A 70 kDa DNA-binding subunit, is crucial for maintaining genomic stability and ensuring accurate DNA replication. Dysfunction in RPA1N has been implicated in cancer development, making it a promising target for research into cancer therapies. By studying the function of RPA1N, researchers can gain insights into the mechanisms underlying cancer progression and potentially identify new therapeutic strategies for combating the disease.
RPAIN: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. 7 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damage; DNA replicationChromosomal Location of Human Ortholog: 17p13.2Cellular Component: nucleolus; nucleusMolecular Function: protein complex bindingBiological Process: DNA recombination; DNA repair; DNA-dependent DNA replication; protein import into nucleus
