The RRAGB Polyclonal Antibody (PACO03338) is a valuable tool for researchers studying RRAGB, a key regulator of mTOR signaling pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the RRAGB protein, this antibody allows for accurate detection and analysis in a variety of cell types, providing valuable insights into pathways related to cell growth, proliferation, and metabolism.RRAGB is a crucial component of the mTOR pathway, which plays a central role in cellular processes such as protein synthesis, autophagy, and cell growth.
Dysregulation of this pathway is linked to various diseases, including cancer, metabolic disorders, and neurological conditions. By studying RRAGB, researchers can gain a better understanding of these diseases and potentially identify new therapeutic targets for intervention.Overall, the RRAGB Polyclonal Antibody is a reliable tool for investigating the role of RRAGB in cellular signaling pathways, offering valuable insights into mTOR-related processes and potential implications for disease research and drug development.
Antibody Name:
RRAGB Antibody
Antibody SKU:
PACO03338
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Rag B.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RRAGB; Ras-related GTP-binding protein B; Rag B; RagB
UniProt Protein Function:
RRAGB: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xp11.21Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleusMolecular Function: GTP binding; GTPase activity; guanyl ribonucleotide binding; protein bindingBiological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway
UniProt Protein Details:
NCBI Summary:
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
