The SAMD4A Polyclonal Antibody (PAC012019) is a valuable tool for research involving SAMD4A, a protein involved in RNA processing and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to SAMD4A, this antibody enables the detection and analysis of the protein in various cell types, making it a versatile tool for studies in immunology and cancer research.SAMD4A plays a crucial role in RNA turnover and immune signaling, making it a promising target for investigating various diseases, including cancer and autoimmune disorders.
By understanding the functions of SAMD4A, researchers can gain insights into how RNA processing impacts immune responses and disease development. This antibody can aid in uncovering the mechanisms by which SAMD4A contributes to these processes, ultimately leading to the development of novel therapeutic interventions.
Function: Acts as a translational repressor of SRE-containing messengers. Ref.6Subcellular location: Cytoplasm. Cell projection › dendrite By similarity. Cell junction › synapse › synaptosome By similarity. Note: Enriched in synaptoneurosomes By similarity. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. Ref.6Sequence similarities: Belongs to the SMAUG family.Contains 1 SAM (sterile alpha motif) domain.Sequence caution: The sequence AAH57838.1 differs from that shown. Reason: Intron retention.The sequence AAP97302.1 differs from that shown. Reason: Intron retention.
UniProt Protein Details:
NCBI Summary:
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]
