The SAMD4B Polyclonal Antibody (PAC020386) is a valuable tool for researchers studying SAMD4B, a protein involved in RNA metabolism and mRNA degradation. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the SAMD4B protein, this antibody allows for the detection and analysis of SAMD4B expression in various cell types, making it ideal for investigations in gene regulation and cellular processes.
SAMD4B is known to play a crucial role in post-transcriptional gene regulation, particularly in the degradation of specific mRNAs. Dysregulation of SAMD4B expression has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By studying the function of SAMD4B, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel treatment strategies.
Antibody Name:
SAMD4B Antibody (PACO20386)
Antibody SKU:
PACO20386
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SAMD4B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20386(SAMD4B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SMGB; hSmaug2
Synonyms:
sterile α motif domain containing 4B
UniProt Protein Function:
SAMD4B: Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. Belongs to the SMAUG family.
UniProt Protein Details:
Protein type:Unknown function
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytoplasm; nucleus
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
