The SASH1 Antibody (CAB15248) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly sensitive and specific for detecting SASH1 in human samples, making it a valuable tool for cancer research and understanding cellular signaling mechanisms.SASH1, also known as SAM and SH3 domain-containing protein 1, is involved in multiple cellular processes such as cell proliferation, migration, and apoptosis. Its dysregulation has been linked to various cancers, making it a potential therapeutic target for cancer treatment.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
SASH1 Antibody
SKU:
CAB15248
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
DUH, DUH1, CAPOK, SH3D6A, dJ323M4.1, SASH1
Positive Sample:
U-87MG, Mouse lung
Cellular Localization:
Cytoplasm.
Calculated MW:
137kDa
Observed MW:
170kDa
This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients.
Purification Method
Affinity purification
Gene ID
23328
RRID
AB_2762145
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SASH1 Rabbit pAb (CAB15248) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
