The SCAMP4 Polyclonal Antibody (PACO40066) is a valuable tool for researchers studying SCAMP4, a protein involved in intracellular membrane trafficking and signaling pathways. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the SCAMP4 protein, this antibody allows for the detection and analysis of SCAMP4 in various cell types, making it a key component in studies related to cell biology and signal transduction.SCAMP4, also known as secretory carrier membrane protein 4, plays a crucial role in regulating vesicle trafficking and membrane dynamics within cells.
Its involvement in intracellular transport processes makes it an important target for research in fields such as cell biology, neurobiology, and developmental biology. Understanding the functions of SCAMP4 can provide insights into cell signaling mechanisms and may lead to the development of novel therapeutic strategies targeting intracellular trafficking pathways.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO40066 at dilution of 1:100.
Immunofluorescent analysis of U251 cells using PACO40066 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probably involved in membrane protein trafficking.
Synonyms:
Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4), SCAMP4
UniProt Protein Function:
SCAMP4: Probably involved in membrane protein trafficking. Belongs to the SCAMP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; VesicleChromosomal Location of Human Ortholog: 19p13.3Cellular Component: integral to membraneBiological Process: protein transport
UniProt Protein Details:
NCBI Summary:
Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
