The SCN4A Antibody (PAC022616) is a valuable tool for researchers studying SCN4A, a gene encoding a voltage-gated sodium channel involved in muscle function and movement. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the SCN4A protein, this antibody allows for precise detection and analysis in a variety of cell types, making it essential for studies focusing on neurobiology, muscle physiology, and channelopathies.SCN4A plays a crucial role in muscle excitation and contraction through its regulation of sodium ion influx.
Mutations in this gene have been associated with various muscle disorders, including myotonia and periodic paralysis. Research on SCN4A is instrumental in understanding the pathophysiology of these conditions and in developing potential therapies to treat them. This antibody provides researchers with a reliable tool to explore the function and regulation of SCN4A, leading to advancements in muscle-related research and potential therapeutic interventions.
Antibody Name:
SCN4A Antibody (PACO22616)
Antibody SKU:
PACO22616
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human SCN4A.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from K562 cells, using SCN4A antibody.
Background:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
Synonyms:
Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1
UniProt Protein Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
NCBI Summary:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
