The SCN9A Polyclonal Antibody (PACO55882) is a valuable tool for researchers studying SCN9A, a gene encoding the Nav1.7 voltage-gated sodium channel. This channel is important for pain perception and has been implicated in various pain disorders. The antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.By targeting the SCN9A protein, this antibody allows for the detection and analysis of Nav1.7 channels in different cell types, making it suitable for investigations in pain biology and neuroscience.
Understanding the role of SCN9A in pain signaling pathways is crucial for developing new therapies for chronic pain conditions and improving the management of pain in patients.Overall, the SCN9A Polyclonal Antibody offers researchers a reliable tool for studying the Nav1.7 channel and its implications in pain disorders, paving the way for advancements in pain management and therapeutic interventions.
IHC image of PACO55882 diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO55882 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO55882 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated ABC system.
Background:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Synonyms:
Sodium channel protein type 9 subunit α (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit α Nav1.7), SCN9A, NENA
