The SDCCAG8 Polyclonal Antibody (PACO03368) is a valuable tool for researchers studying SDCCAG8, a protein associated with ciliopathies and ciliary function. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting SDCCAG8 in human samples, making it ideal for use in Western blot applications. By binding to the SDCCAG8 protein, this antibody enables researchers to analyze its expression and function in various cell types, offering insights into its role in ciliary biology and disease pathology.SDCCAG8, also known as NPHP10, is a key player in the regulation of cilia structure and function, with mutations in the gene causing a spectrum of ciliopathy disorders.
Understanding the molecular mechanisms underlying SDCCAG8's function is crucial for unraveling the pathogenesis of these disorders and developing targeted therapies. By utilizing the SDCCAG8 Polyclonal Antibody in their research, scientists can further our understanding of ciliary biology and potentially uncover new therapeutic strategies for ciliopathy-related conditions.
Antibody Name:
SDCCAG8 Antibody
Antibody SKU:
PACO03368
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human NY-CO-8.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SDCCAG8; CCCAP; NPHP10; HSPC085; Serologically defined colon cancer antigen 8; Antigen NY-CO-8; Centrosomal colon cancer autoantigen protein; hCCCAP
UniProt Protein Function:
SDCCAG8: Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis. Defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7 (SLSN7). SLSN7 is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q43Cellular Component: centriole; centrosome; cytosol; intercellular junctionMolecular Function: protein bindingBiological Process: establishment of cell polarity; G2/M transition of mitotic cell cycle; lumen formationDisease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 16; Senior-loken Syndrome 7
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
