The SEC61G Antibody (PACO12088) is a polyclonal antibody designed for research involving SEC61G, a component of the Sec61 translocon complex involved in the translocation of proteins across the endoplasmic reticulum membrane. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blotting and immunohistochemistry.SEC61G is essential for protein translocation and quality control processes within the endoplasmic reticulum, making it a crucial component in cellular homeostasis. Dysregulation of SEC61G has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.
Therefore, studying SEC61G and its functions can provide valuable insights into disease mechanisms and potential therapeutic targets.By using the SEC61G Antibody (PACO12088), researchers can accurately detect and analyze SEC61G protein levels in different cell types and tissues, enhancing their understanding of protein translocation processes and their implications in disease pathology. This antibody is a valuable tool for studies in cell biology, biochemistry, and drug discovery, providing a deeper understanding of protein translocation mechanisms and their role in various cellular processes.
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER).
UniProt Protein Details:
NCBI Summary:
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
