The SEMA3D Polyclonal Antibody (PACO18887) is a valuable tool for researchers studying SEMA3D, a protein involved in cell guidance and signaling. This antibody, derived from rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to SEMA3D, this antibody allows for the detection and analysis of the protein in a variety of cell types, making it ideal for studies in developmental biology, neurobiology, and cancer research.
SEMA3D is a member of the semaphorin family of proteins, known for their roles in axon guidance, cell migration, and angiogenesis. SEMA3D specifically has been implicated in the regulation of cell proliferation and survival, as well as tumor progression and metastasis. Understanding the function of SEMA3D is crucial for elucidating its role in various physiological and pathological processes, making this antibody a valuable tool for researchers investigating these mechanisms.
Antibody Name:
SEMA3D Antibody (PACO18887)
Antibody SKU:
PACO18887
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SEMA3D
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18887(SEMA3D Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18887(SEMA3D Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene Belongs to the semaphorin family. Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Strong binding to neuropilin is mediated by the carboxy third of the protein.
Synonyms:
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
UniProt Protein Function:
SEMA3D: a secreted protein that induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 7q21.11Cellular Component: extracellular spaceMolecular Function: chemorepellent activity; semaphorin receptor bindingBiological Process: negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration
