The SEMA3D Polyclonal Antibody (PACO18888) is a valuable tool for researchers studying SEMA3D, a member of the semaphorin family of proteins that play important roles in cell signaling and neural development. This antibody, produced in rabbits, has high specificity for detecting SEMA3D in human samples and is validated for use in Western blotting applications.SEMA3D is known for its functions in axon guidance during development, as well as its involvement in cancer progression and metastasis. By targeting SEMA3D with this antibody, researchers can gain insights into its role in these physiological and pathological processes.
This antibody is highly versatile and can be used in various cell types, making it a valuable tool for studies in neuroscience, cancer biology, and beyond.Overall, the SEMA3D Polyclonal Antibody (PACO18888) offers researchers a reliable and specific tool for investigating the function and expression of SEMA3D in various biological contexts. Its high reactivity and validation for Western blotting make it a valuable asset for advancing our understanding of SEMA3D's roles in development, disease, and cellular signaling pathways.
Antibody Name:
SEMA3D Antibody (PACO18888)
Antibody SKU:
PACO18888
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SEMA3D
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18888(SEMA3D Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene Belongs to the semaphorin family. Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Strong binding to neuropilin is mediated by the carboxy third of the protein.
Synonyms:
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
UniProt Protein Function:
SEMA3D: a secreted protein that induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 7q21.11Cellular Component: extracellular spaceMolecular Function: chemorepellent activity; semaphorin receptor bindingBiological Process: negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration
