Description
SENP5 Antibody (PACO13604)
The SENP5 Polyclonal Antibody (PAC013604) offered by Assay Genie is a valuable tool for researchers investigating SENP5, a protein involved in the regulation of various cellular processes, including cell cycle progression and DNA repair. This antibody is raised in rabbits and has been validated for use in Western blot applications, allowing for the detection and analysis of SENP5 in human samples.SENP5, also known as SUMO-specific protease 5, plays a crucial role in the post-translational modification process known as SUMOylation, which regulates the activity of numerous proteins involved in cell signaling and gene expression.
Dysregulation of SENP5 has been linked to various diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic intervention.By using the SENP5 Polyclonal Antibody, researchers can gain valuable insights into the role of SENP5 in cellular processes and disease pathogenesis, ultimately leading to the development of novel therapeutic strategies aimed at targeting SENP5 in the treatment of various diseases.
| Antibody Name: | SENP5 Antibody (PACO13604) |
| Antibody SKU: | PACO13604 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human SENP5-Specific |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SUMO1/sentrin specific peptidase 5;SENP5;DKFZp564O1016;FLJ42398;MGC27076 ; |
| UniProt Protein Function: | SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Protease; EC 3.4.22.68 Chromosomal Location of Human Ortholog: 3q29 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: protein desumoylation; protein sumoylation |
| NCBI Summary: | The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q96HI0 |
| NCBI GenInfo Identifier: | 296452962 |
| NCBI Gene ID: | 205564 |
| NCBI Accession: | Q96HI0.3 |
| UniProt Secondary Accession: | Q96HI0,Q96SA5, B4DY82, |
| UniProt Related Accession: | Q96HI0 |
| Molecular Weight: | 81,310 Da |
| NCBI Full Name: | Sentrin-specific protease 5 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 5 |
| NCBI Official Symbol: | SENP5Â Â |
| NCBI Protein Information: | sentrin-specific protease 5 |
| UniProt Protein Name: | Sentrin-specific protease 5 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP5 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP5Â Â |
| UniProt Entry Name: | SENP5_HUMAN |
