The SENP7 Polyclonal Antibody (PAC023149) is a valuable tool for researchers studying SENP7, a crucial protein involved in the regulation of cellular processes such as DNA repair, cell cycle progression, and gene expression. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.SENP7, also known as SUMO-specific protease 7, is a key player in the SUMOylation pathway, where it cleaves SUMO from target proteins, impacting their localization, stability, and function.
Dysregulation of SENP7 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for further investigation.By targeting the SENP7 protein, researchers can gain insights into its role in cellular processes and disease pathogenesis, paving the way for potential therapeutic interventions. The SENP7 Polyclonal Antibody is a valuable tool for studies in molecular biology, cancer research, and drug development aimed at understanding and targeting SENP7-dependent pathways.
Synthesized peptide derived from Internal of human SENP7.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, using SENP7 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using SENP7 antibody.
Background:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
NCBI Summary:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
