The SENP7 Polyclonal Antibody (PACO56410) is a valuable tool for researchers studying SENP7, a crucial protein involved in the SUMOylation pathway and regulation of various cellular processes. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to SENP7, researchers can easily detect and analyze the protein in different cell types, making it an essential tool for studies in molecular biology and cancer research.
SENP7, a member of the SENP family of proteases, plays a key role in the regulation of SUMOylation, a post-translational modification process that influences protein function and cellular activities. Dysregulation of SENP7 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target for drug development. Understanding the function and activity of SENP7 is essential for uncovering its role in disease progression and identifying novel treatment strategies.
Antibody Name:
SENP7 Antibody (PACO56410)
Antibody SKU:
PACO56410
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Sentrin-specific protease 7 protein (128-366AA)
IHC image of PACO56410 diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
NCBI Summary:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
