The Serinc3 Polyclonal Antibody (PAC020440) is a valuable tool for researchers studying Serinc3, a protein involved in lipid metabolism and viral infection. This antibody, produced in rabbits, exhibits excellent specificity and sensitivity for detecting Serinc3 in human samples, making it an ideal choice for use in Western blot applications. By binding to the Serinc3 protein, this antibody enables accurate detection and analysis in a variety of cell types, allowing for further exploration of its roles in lipid homeostasis and viral replication.Serinc3, also known as Serine Incorporator 3, plays a critical role in regulating lipid levels and suppressing viral infectivity.
Its involvement in lipid metabolism and viral infection makes it a promising target for research into metabolic disorders and viral replication mechanisms. Understanding the functions of Serinc3 is essential for developing potential therapies targeting lipid metabolism-related diseases and viral infections. In summary, the Serinc3 Polyclonal Antibody is a reliable tool for investigating the functions of Serinc3 in various cellular processes, offering valuable insights into lipid metabolism and viral infection mechanisms. Its high specificity and sensitivity make it an essential component for studies in the fields of metabolism, virology, and infectious diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20440(SERINC3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: Human right lung cancer tissue, Human left lung cancer tissue, Primary antibody: PACO20440(SERINC3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20440(SERINC3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis.
Synonyms:
serine incorporator 3
UniProt Protein Function:
SERINC3: May be involved in cellular transformation. Belongs to the TDE1 family.
UniProt Protein Details:
Protein type:Cell surface; Membrane protein, multi-pass; Membrane protein, integral
