The SERP1 Polyclonal Antibody (PAC014900) is specially developed for researchers studying the SERP1 protein, which is involved in the regulation of endoplasmic reticulum stress response. This antibody is produced in rabbits and is highly specific for human samples, making it a valuable tool for Western blot applications. By targeting the SERP1 protein, researchers can investigate its role in cellular stress responses and potentially uncover new therapeutic targets for diseases associated with aberrant ER stress.SERP1, also known as stress-associated endoplasmic reticulum protein 1, is a key player in the unfolded protein response pathway, helping to maintain protein homeostasis and cellular integrity under stressful conditions.
Dysregulation of this pathway has been linked to various diseases, including neurodegenerative disorders, diabetes, and cardiovascular diseases. By studying the function of SERP1, researchers can gain insights into the mechanisms underlying these diseases and develop strategies to modulate ER stress for therapeutic purposes.
Antibody Name:
SERP1 Antibody (PACO14900)
Antibody SKU:
PACO14900
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SERP1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14900(SERP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14900(SERP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
Synonyms:
stress-associated endoplasmic reticulum protein 1
UniProt Protein Function:
RAMP4: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Belongs to the RAMP4 family.Protein type: Chaperone; Membrane protein, integralChromosomal Location of Human Ortholog: 3q25.1Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasmic microtubule; integral to membrane; ribosomeBiological Process: positive regulation of translation; unfolded protein response; multicellular organismal aging; protein modification process; positive regulation of insulin secretion; protein amino acid glycosylation; glucose metabolic process; positive regulation of organ growth; post-embryonic development; positive regulation of growth hormone secretion; protein transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; plasma membrane organization and biogenesis; response to stress; skeletal development; muscle morphogenesis
