The SETD1B Polyclonal Antibody (AB10009) is specifically designed for research involving the SETD1B protein, a histone methyltransferase that plays a crucial role in chromatin regulation and gene expression. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SETD1B protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an ideal tool for studies in epigenetics and cancer research.
SETD1B is known for its involvement in histone methylation, a key epigenetic modification that influences gene transcription and cellular processes. Dysregulation of SETD1B has been linked to various diseases, including cancer and developmental disorders, highlighting its importance as a potential therapeutic target. Investigating the role of SETD1B in chromatin dynamics and gene regulation is essential for developing targeted therapies that can modulate gene expression and potentially treat these diseases.
Product Name:
SETD1B Polyclonal Antibody
SKU:
CAB24505
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SETD1B (NP_001340274.1).
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Purification Method:
Affinity purification
Gene ID:
23067
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse lung using SETD1B Rabbit pAb (CAB24505) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
