The SEZ6L Polyclonal Antibody (PAC020450) is a valuable tool for researchers interested in studying the SEZ6L protein, a cell surface molecule involved in synaptic function and neuronal development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SEZ6L protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in neuroscience and neurodevelopmental disorders.
SEZ6L, also known as seizure-related gene 6-like protein, plays a crucial role in synaptic plasticity and neuronal connectivity in the brain. Its involvement in regulating neuronal function makes it a promising target for research on neurological disorders such as epilepsy, autism, and schizophrenia. By studying the function and expression of SEZ6L, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic strategies for treating them.
Antibody Name:
SEZ6L Antibody (PACO20450)
Antibody SKU:
PACO20450
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SEZ6L
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20450(SEZ6L Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SEZ6L (seizure related 6 homolog-like) is a 1,024 amino acid, single-pass type I membrane protein that localizes to the endoplasmic reticulum. Widely expressed, SEZ6L is a candidate tumor suppressor gene and may contribute to specialized endoplasmic reticulum functions in neurons. SEZ6L contains three CUB domains and five sushi (CCP/SCR) domains, which may be involved in protein-protein interactions and signal transduction. The gene encoding SEZ6L is located on human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
Synonyms:
seizure related 6 homolog (mouse)-like
UniProt Protein Function:
SEZ6L: May contribute to specialized endoplasmic reticulum functions in neurons. Belongs to the SEZ6 family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; cell soma; integral to membraneBiological Process: synapse maturation; adult locomotory behavior; cerebellar Purkinje cell layer development
