The SFXN4 Antibody (PACO36758) is a high-quality polyclonal antibody designed for research involving the SFXN4 protein, a member of the sideroflexin family implicated in mitochondrial function. The antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in various experimental settings.SFXN4, also known as sideroflexin 4, plays a critical role in mitochondrial iron transport and heme biosynthesis, making it an important target for studies related to cellular metabolism and energy production.
Its involvement in these processes suggests its potential impact on diseases like cancer, neurodegenerative disorders, and metabolic syndromes.The SFXN4 Antibody is validated for use in Western blotting applications, enabling precise detection and analysis of the SFXN4 protein in various cell types and tissues. Its specificity and reliability make it a valuable tool for researchers investigating the role of SFXN4 in mitochondrial function and its implications for human health.
Western blot. All lanes: SFXN4 antibody at 0.3µg/ml. Lane 1: K562 whole cell lysate. Lane 2: U251 whole cell lysate. Lane 3: U87 whole cell lysate. Lane 4: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 38, 35, 25 kDa. Observed band size: 38 kDa.
Immunohistochemistry of paraffin-embedded human thymus tissue using PACO36758 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO36758 at dilution of 1:100.
Background:
Potential iron transporter.
Synonyms:
Sideroflexin-4 (Breast cancer resistance marker 1), SFXN4, BCRM1
UniProt Protein Function:
SFXN4: Potential iron transporter. Belongs to the sideroflexin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 10q26.11Cellular Component: intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membraneMolecular Function: ion transmembrane transporter activityBiological Process: iron ion homeostasisDisease: Combined Oxidative Phosphorylation Deficiency 18
