The SH3BP5 Polyclonal Antibody (PACO47650) is a valuable tool for researchers studying the SH3BP5 protein, which plays a role in cell signaling pathways and is associated with cancer development. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SH3BP5 protein, this antibody allows for the detection and analysis of SH3BP5 in various cell types, making it ideal for research in oncology and cell biology.
SH3BP5, also known as SH3 domain-binding protein 5, is involved in regulating cell growth and survival by interacting with various signaling molecules. Its dysregulation has been linked to the development and progression of cancer, making it a target of interest for cancer research. By studying the function of SH3BP5, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially identify new therapeutic targets for cancer treatment.
Western Blot. Positive WB detected in: Mouse heart tissue, Mouse brain tissue, Mouse kidney tissue. All lanes: SH3BP5 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 33 kDa. Observed band size: 51 kDa..
Immunofluorescent analysis of Hela cells using PACO47650 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO47650 at dilution of 1:100.
Background:
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Synonyms:
SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK), SH3BP5, SAB
UniProt Protein Function:
SH3BP5: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Belongs to the SH3BP5 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p24.3Cellular Component: mitochondrion; cytoplasmMolecular Function: protein binding; protein kinase inhibitor activity; SH3 domain bindingBiological Process: negative regulation of protein kinase activity; signal transduction
