The SH3TC2 Polyclonal Antibody (PACO05369) is a valuable tool for research involving SH3TC2, a protein involved in the regulation of myelination in the peripheral nervous system. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the SH3TC2 protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in neurology and neurodegenerative diseases.
SH3TC2 is a key player in the process of myelination, which is essential for the proper functioning of the peripheral nervous system. Defects in SH3TC2 have been associated with inherited peripheral neuropathies, highlighting the importance of understanding its function and regulation. Research into SH3TC2 could provide insights into potential therapeutic targets for treating neuropathies and other disorders affecting the peripheral nervous system.
Antibody Name:
SH3TC2 Antibody (PACO05369)
Antibody SKU:
PACO05369
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human SH3TC2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SH3TC2; KIAA1985; PP12494; SH3 domain and tetratricopeptide repeat-containing protein 2
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]
