The SH3TC2 Polyclonal Antibody (PACO55214) is a research tool designed for studying SH3TC2, a protein involved in the regulation of membrane trafficking and myelination in the peripheral nervous system. The antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting SH3TC2 protein in human samples, making it suitable for various experimental techniques such as Western blotting.SH3TC2, also known as the SH3 domain and tetratricopeptide repeats 2, plays a crucial role in maintaining the structure and function of myelinating Schwann cells, which are essential for proper nerve signal conduction.
Dysregulation of SH3TC2 has been linked to Charcot-Marie-Tooth disease, a genetic neuropathy characterized by peripheral nerve degeneration and muscle wasting.Studying the function and expression of SH3TC2 using the PACO55214 antibody can provide valuable insights into the pathophysiology of Charcot-Marie-Tooth disease and other related neurological disorders. By elucidating the molecular mechanisms underlying SH3TC2-mediated processes, researchers can potentially identify novel therapeutic targets for the treatment of these debilitating conditions.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO55214 at dilution of 1:100.
Immunofluorescent analysis of PC-3 cells using PACO55214 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Synonyms:
SH3 domain and tetratricopeptide repeat-containing protein 2, SH3TC2, KIAA1985
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]
